The Franciscan Order of Friars Minor Conventual was invited to the Archdiocese of Liverpool by Archbishop Keating in 1925 and offered the parish of Mossley Hill, a developing residential area in south Liverpool. The first two Friars, Fr Daniel Lutz and Fr Vincent Mayer, arrived from the USA and were at first based at St Saviour’s Convent, Mossley Hill, saying Mass in the Convent Chapel.

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In 1926 the parish was established, the first church being a temporary building on Sands Roadwhile a site was sought for a permanent church. The present site on Queen’s Drive was bought and the foundation stone laid by Archbishop Downey in 1931. The church was designed by Liverpool architect Anthony Ellis and opened in 1932. It was consecrated in 1967.

The Friars friary was known as, known as “Elmsley House” was on Elmsley Road, served as the Novitiate House of the English Province of the Order of Friars Minor Conventual from 1947 to 1955.

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The first parish primary school was established in 1949 in a temporary building in Green Lane; it moved into purpose-built premises in 1951. In 1971 the school was transferred to its present site next to the church, and the Green Lane buildings became Bishop Eton School.

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In 1964 the parish commissioned three mural paintings for the church, and these were painted by Fr Giovanni Lerario, an Italian member of the OFM Conv. One of the murals features Our Lady of the Immaculate Conception surrounded by members of the Second Vatican Ecumenical Council, held in Rome 1962-1965.